International Research Resources

Sabin, Albert B. et.al. 1962, Pediatrics, 29, pp. 105-115. "Antipoliomylitic activity of human and bovine Colostrum and milk": Dr. Sabin isolated antipolio antibodies in bovine colostrum. (Bovine colostrum was was used in oral administration successfully. Antibodies were isolated and a successful vaccine prepared.

Ebina, et. aI., 1983, The Lancet, Vol. 29 No 2 pp. 1029-1030: "Prevention of Rotavirus Infection By Cow Colostrum Containing Antibody Against Human Rotavirus": Japanese researchers exposed cattle to oral doses of rotavirus which causes severe diarrhea and bowel inflammation in humans. Colostrum from these cows contained antibodies which, when fed to humans, prevented them from getting rotavirus.

Tacket, Binion, Bostwick, et. al. ,Arner Jour of Trap Med Hyg, Sep 1992 V47(3) p276-83: Efficacy of Bovine immunoglobulin concentrate in preventing illness: " Human trial with hyper immune immunoglobulin administered orally with sodium bicarbonate. Conclusion: Orally administered bovine immunoglobulin protects against shigellosis and may be useful in preventing shigellosis among travelers".

Hernell, Olle At the University of Ulmea, Sweden 1995, Science, Apr. pp 231 reported findings that glycoproteins in bovine colostrum inhibited attachment of the Helicobactor Pylori bacteria believed to cause stomach ulcers, and that colostrum contains significant amounts of interlukin-10, a strong inflammation inhibitory agent significant in reducing inflammation in arthritic joints and injury areas.

Zhang, Iguchi, Mochizuki, et. ai, 1990, Prac. Soc. Exp. BioI. Med. Jul.; 194(3): 270-3. Gonadotropin-releasing hormone (GnRH) and it's associated peptide (GAP) found in bovine colostrum Important role in the release of Cytokines (Immune messengers used to elevate immune activity, they also serve both ANTIVIRAL AND ANTITUMOR functions).

Watson, Fransis, Ballard, 1992, Journal of Diary Research Aug. 59(3): 369-80 "Bovine Colostrum cell-growth factors as well as immunomodulatory factors are able to regulate IgE response in heterologous species." Immune regulatory factors are transferable to human and other species

Li-Chan, E.; et al. Food Research International, vol. 28, no 1, 9-16, 1995. Stability of bovine immunoglobulins to thermal treatment and processing. Normal dairy processing does not harm Active Immune factors.

Wilson, D.C., N.D., Ph.D., James, 1998, Journal of Longevity, Vol. 4, NO.2. Immune System Breakthrough:

Colostrum. "The most effective colostrum is bovine. It's much richer in immune factors than human colostrum, particularly in the body's most important immunoglobulin, IgG (Sand holm, 1979)." "Bovine colostrum can supply an overtaxed body with more immunoglobulins than human colostrum."

" ... Research at State Univ. of NY, Buffalo has shown that colostrum provides 'specific antibody reactivity' to certain bacteria, viruses and yeast responsible for conditions that affect the lungs, gastrointestinal tract, bones, and blood (Oraga, 1983)." "IGF-1 has ... anabolic, and tissue repair characteristics ... IGF-1 is the only growth factor that can stimulate muscle growth and repair all by itself. Its role in differentiation, repair, synthesis, and interplay with other necessary growth factors, results in regenerative effects on nearly all structural cells of the body (Tollefsen, 1989)." "COLOSTRUM HAS BEEN SHOWN CONCLUSIVELY TO HAVE A SYSTEMIC EFFECT ON THE IMMUNE SYSTEM."

Xu, Mardell et. aI., Immunology 1995 vol 85 p 394-9: Expression offunctionallgF-1 receptor on lymphoid cells:" Our studies suggest that biological activities of IGF-1 include direct stimulation of immune cells and that expression of IGF-1 receptor may have a role in the regulation of T-cell function."

Watson, Dennis L, et al. 1990, Journal of Dairy Research, 59, 369-380, Factors in ruminant colostrum that influence cell growth and murine IgE antibody responses. "We conclude that bovine colostrum contains cell ¬growth factors as well as immunomodulatory factors that are able to regulate the IgE response in a heterologous species." Sabin, Albert B. 1950, Journal of Diseases of Children, 80, p.866 "Antipoliomylitic Substance in milk from Human Beings and Certain Cows": As early as 1950 Dr. Albert Sabin, a discoverer of polio vaccine, reported an antipolio substance in the milk of cows, despite the fact that cows do not get poliomylitis.

Samson, R.R. e1. aI., Immunology, 1975,Vol 38, No 2, 291-296. Dr. Samson and associates found colostrum was 21 times richer in Vitamin B-12 than milk. Research in 1975 confirmed that adequate B 12 in body doubles body's immune systems ability to fight disease.

Ho, Lawton, 1978 Human Colostral Cells, Journ. of Pediatrics Vol 93, NO.6 pp 910-15 Dr's in hospital use showed that colostrum Leukocytes are effective against E Coli and the yeast Candia albicans.

Lawton, e1. aI., 1979, Archives of Disease in Childhood, 54, pp.127 -130. "Interferon Synthesis by Human Colostral Leukocytes": Exposure of Colostrum leukocytes to certain mitogens stimulated production of interferon, the substance that slows or prevents viral growth

Bouda e1. aI., 1980, Acta Veterinaria Brno. Vol 49 Nos 1-2 pp 53-58. 'Vitamins E and C in the blood plasma of Cows": Vitamin E is 2.5 times greater in bovine colostrum than in milk. It helps protect the vitamin A and other ingredients from oxidation. "Vitamin A and Carotene Metabolism in Cows" pp 45-52; Vitamin A in bovine colostrum is ten times the amount in serum. Vitamin A shown to restore and revitalize the thymus gland the master gland of the immune system.

Palmer, EL. e1. aI., 1980, Journal of Medical Virology. 5 pp 123-129. "Antiviral Activity of Colostrum and Serum Immunoglobulins A and G." Colostrum has an enteric secretory virus antibody that acts against virusal invaders. A wide range of antiviral factors were acknowledged to be present in colostrum. This research was done at the US Government's Center for Disease Control in Atlanta, Georgia

Dluholucky, S. e1. aI., 1980, Archives of Disease in Childhood, 55, pp 458-460; 1980; Antimicrobial activity of colostrum after the administration of inactive Escherichia Coli oral vacine to expectant mothers: Mothers developed immune factors that develop on mucosal sources that enter blood serum and concentrate in expectant mothers' mammary glands. Describes how colostrum may develop immunities.

Morris, J.A. e1. aI., 1980, Journal of Medical Microbiology Vol 13 No 2 pp 265-271. "Passive Protection of Lambs Against Enteropathogenic Escherichia Coli: Mother sheep and cows given doses of E. coli orally developed antibodies for E coli in their colostrum. When nursing offspring were then dosed with E. coli, immune factors from the mothers' colostrum prevented the E. coli from attaching to the bowel wall and protection resulted.

Jackson, Baker, Lessof, et al. 1981, The Lancet, June 13. Intestinal Permeability in Patients with Eczema and Food Allergy .••... results suggestthat there is an intestinal mucosal defect in eczema which exists whether or not there is coexistent food allergy."

McClead, Richard, E1. AI., 1982, Pediatric Research, Vol. 6 No 4 P 227, " Resistance of Bovine Anti-Cholera Toxin IgG I (Anti-CT) to in Vitro and In Vivo Proteolysis": Colostrum from cows exposed to cholera contained IgG antibodies which protected against that type of cholera.

Theodore, Christine, Et. AI., 1982, Raven Press, NY: "Immunologic Aspects of Colostrum and Milk: Development of Antibody Response to Respiratory Synctial Virus (RSV) and Bovine Serum Albumin in the Human and Rabbit mammary Gland": People and animals exposed to RSV virus, often responsible for bronchitis and pneumonia, developed IgA and IgG (immunoglobulin) antibodies against this virus in their colostrum

Ogra, Lesonsky, Fishout, Research, 1983, State University of NY at Buffalo: "Colostrum provided specific antibody reactivity to the bacteria, viruses and yeasts responsible for the following conditions: Appendicitis, Aseptic or Viral Meningitis, Bronchitis, Bronchia or Viral Pneumonia, Candida Albicans, Chicken Pox, Cholera, Diarrhea, Dysentery, Diphtheria, Gastroenteritis, Japanese B Encephalitis, Mucus Membrane Infections, Parathyroidism, Pneumonia, Polio, Septicemia (blood poisoning), Tetanus, Typhoid, Viral Myelitis, and Whooping cough

Kim, e1. aI., 1985, Journal of Infectious Diseases, Vol. 150, No 1 pp. 57-61: "In Vitro and In Vivo Neutralizing Activity of Human Colostrum and milk Against Purified Toxins A & B of Clostridium Difficile": substances from colostrum neutralized the two main toxins of the infectious clostridium bacteria.

Lie, Syed, Animal Genetics, 1986, V. 17 pp 47-59: Some properties of the Iysozymes in colostrum from cows: "High bacteriolytic activity, fully expressed in colostrum. heat stable in acidic PH. Acosta-Altamirano, et. aI., 1987, Advances in Experimental Medicine and Biology, 216B pp. 1347-52:

"Antiamoebic Properties of Human Colostrum" Colostrum effective against amoebic invaders. Buescher, Mcllheran, 1988, Pediatric Research, Vol. 24 No 1 pp. 14-19: "Antioxidant Properties of Colostrum" Colostrum found to contain numerous powerful, naturally occurring, antioxidants.

Shortridge, Lawton, Choi, 1990, Journal of Trop. Pediatric. APR; 36(2): 94-5 Reported: A. Incidence of infection and gastrointestinal illness markedly reduced in breast fed babies. B. Colostrum contains Non Specific Inhibitors (NSI's): factors that are inhibitory for a wide range of respiratory illness notably influenza viruses. C. Colostrum specifically cited for its unique effectiveness against potential deadly outbreaks of (new) Asian flu viruses that emerge from animallhuman mutations.

Deitch, MD, FACS, Edwin A., Arch. Surg., 1990, Vol 125, The Role of Intestinal Barrier Failure and Bacterial Translocation in the Development of Systemic Infection and Multiple Organ Failure .••.. .increasingly clear that the gastrointestinal tract is not a passive organ ...••••... the GI tract recognized as having important endocrine, metabolic, immunologic and barrierfunctions ...••••... bacteria/endotoxin escaping from the gut could lead to systemic infection and disease ...••••... studies indicate that one or more of three basic pathophysiologic factors appear to be necessary for bacterial translocation to occur." "Three promoting factors are disruption of the ecologic balance of the .•. microflora, resulting in overgrowth with certain bacteria, impaired host immune defenses, and physical disruption of the gut mucosal barrier."

Science, Vol. 257 Jul. 10, 1992: "Transferred immune cells help fight viral infections": cytomegalovirus (CMV) cause of fatal pneumonia in bone morrow patients reduced with introduction of specific immune cells via administration of bovine colostrum.

Applegate, Runners World, June 1992, V27 p22 Protein Power: "Protein depletion weakens the immune system and causes irritability."

Berl, Munch, et al. 1992 Ju11; 105(7) pp219-24 Bovine colostrum and protection of young animals:" Calves without colostrum died in 90% of cases. Feeding commercially prepared colostrum can provide immediate compensation. The application of vaccine(s) directly into the mammary gland at ablactation provokes specific IgA and IgM antibodies which are normally not channeled from the blood system of the mother into the colostrum. This kind of immunization may become more and more important ••.

Galland, M.D., FACN, Leo, 1995, Townsend Letter for Doctors, Aug.-Sept. Leaky Gut Syndromes: Breaking the Vicious Cycle. "Leaky Gut Syndromes are usually provoked by exposure to substances which damage the integrity of the intestinal mucosa ... causes of damage are infectious agents (viral, bacterial and protozoan),43-4S ethanol,47,48 and NSAIDs.20,49,5o Hypoxia of the,51,52 elevated levels of reactive oxygen metabolites,53 and cytotoxic drugs54.5s also increased para-cellular permeability." "Altered intestinal permeability is a key element in the pathogenisis of many different diseases. Hyperpermeability initiates a vicious cycle in which allergic sensitization, endotoxic immune activation, hepatic dysfunction, pancreatic insufficiency and malnutrition occur; each of these increases leakiness of the small bowl. Effective treatment of the Leaky Gut Syndromes requires several components: avoidance of enterotoxic drugs and allergic foods, elimination of infection or bacterial overgrowth with antimicrobial and probiotics, and dietary supplementation with trophic nutrients."

Kamen, PhD, Betty; Kamen, MEng, Paul. 1998. CYTOLOG: INFOPEPTIDES; A POTENT, SAFE, BROAD¬SPECTRUM THERAPEUTIC TOOL. Colostrum's immune components contain the "information" required by the human immune system to identify and eliminate unfriendly biological pathogens.

Pineo, A. et. al. 1975 Biochemical Biophysiology Acta (Amsterdam.) 379: 201-206. Research by Drs. Pineo, Ortego, and Uriel in 1975 discovered a special glycoprotein in cow colostrum. They found it had "Protease Inhibitor Activity" that was extremely effective at protecting the immune and growth factors in colostrum from destruction by digestive acids pancreatic enzymes in the adult human stomach.